Abstract

Background: Breast cancer (BC) stage III treatment options are very widely and may consist of mastectomy and radiation for local treatment and hormone therapy or chemotherapy for systemic treatment. Among this stage category BC stage IIIC (T1-4N3M0) is considered advanced, that is why necessary to find effective treatment options for this stage patients. In this study results support us believed that BC stage III tumors are TUBB3-expressed tumor and the combination of gemcitabine and cisplatine has to be highly active regiment as first-line treatment BC stage III (T₁-4N₃M₀) patients. The treatments option that systemic chemotherapies and local therapy methods to follow each other can be reasonable scheme for BC stage IIIC (T1-4N3M0) patients.